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Budesonide in IgA Nephtopathy

A myIgANteam Member asked a question 💭

I have been diagnosed with IgA N secondary to other inflammatory disorder( UC and AK). In addition to other medications, I have been put on steroids (3 doses of Methyl prednisolone, followed by Budesonide 9mg daily( sustained release Cap, as Tarpeyo is unavailable) , any idea if this would work with the early disease(as shown in Histopathology) but with EGFR of 55!
Thank you

March 29 (edited)
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A myIgANteam Member

@A myIgANteam Member It sounds like you have a good visit coming up at just the right time! Hopefully the lab results give you and your doctor a clearer picture. Wishing you well at your appointment! 😊

April 22
A myIgANteam Member

Thank you Clari for you response. Actually one Nephrologist recomended oral prednisolone while 2 others recomeneded Budesonide as it has fewer systemic side effects! But yet I'm not sure which is better though I started the second one. I have a next visit in a few days and the Lab tests will probably answer this question?
Thanks again😊

April 20
A myIgANteam Member

@A myIgANteam Member Thanks for sharing your question. Since your situation includes secondary IgA nephropathy along with other inflammatory conditions, it makes sense to check closely with your nephrologist about how budesonide fits into your overall treatment plan and what they’ll be watching over time. If others here have taken budesonide or a similar steroid approach, they may be able to share what their experience was like. Has your doctor said what results they’re hoping to see with this treatment? 🙂

April 9
myIgANteam

Will budesonide work with early disease but an eGFR of 55?

Budesonide is a targeted steroid designed specifically for IgA nephropathy that delivers medication directly to the area of inflammation in the gut-kidney pathway. It's been shown to help reduce protein in the urine and slow disease progression in many people with Show Full Answer

Will budesonide work with early disease but an eGFR of 55?

Budesonide is a targeted steroid designed specifically for IgA nephropathy that delivers medication directly to the area of inflammation in the gut-kidney pathway. It's been shown to help reduce protein in the urine and slow disease progression in many people with IgAN.

Your situation is unique because you have secondary IgAN related to ulcerative colitis and another inflammatory condition. The combination of methylprednisolone pulses followed by daily budesonide is a treatment approach that aims to quickly reduce inflammation, then maintain that control.

With early disease on biopsy but an eGFR of 55, you're in a range where kidney-protecting treatments are especially important. Budesonide has been studied in people with various levels of kidney function, and starting treatment early can help preserve what function you have.

However, your response may differ from someone with primary IgAN since your condition is driven by other inflammatory disorders. Your nephrologist will need to monitor your kidney function, protein levels, and overall response closely through regular blood and urine tests.

The steroid approach you're on targets both the immediate inflammation and ongoing immune activity, which could be beneficial given your complex situation.

March 29

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