There's no cure for IgA Nephropathy, but treatment can help slow kidney damage and protect kidney function over time. The approach is personalized based on your labs, symptoms, and stage of disease. Here's an overview of the main treatment options:
Blood Pressure & Protein Control
- ACE inhibitors or angiotensin-receptor Show Full Answer
There's no cure for IgA Nephropathy, but treatment can help slow kidney damage and protect kidney function over time. The approach is personalized based on your labs, symptoms, and stage of disease. Here's an overview of the main treatment options:
Blood Pressure & Protein Control
- ACE inhibitors or angiotensin-receptor blockers (ARBs) are often the first step — they lower blood pressure and reduce protein in the urine
FDA-Approved Medications for IgAN
- Budesonide (Tarpeyo) — a targeted corticosteroid that calms the immune system
- Sparsentan (Filspari) and atrasentan (Vanrafia) — reduce protein in the urine by blocking endothelin receptors
- Iptacopan (Fabhalta) — a complement inhibitor that reduces kidney inflammation
- Sibeprenlimab (Voyxact) and atacicept (Trutakna) — block immune signals that trigger abnormal IgA production
Other Medications
- SGLT2 inhibitors to reduce protein in the urine
- Statins to manage cholesterol
Lifestyle Changes
- Reducing sodium intake
- Exercising regularly
- Quitting smoking In more advanced cases, dialysis or a kidney transplant may be needed. The most important thing is working closely with your kidney team to find the right combination for you — and sticking to your treatment plan, as early action can make a real difference.
October 24
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