A urine protein test is a simple but important way to check how well your kidneys are working. This is important for people with several conditions, including IgA nephropathy (IgAN), a form of chronic kidney disease (CKD). A urine protein test looks for proteinuria (protein in your urine). Having protein in your urine is often one of the first signs of kidney damage from IgAN or other kidney conditions.
Understanding your results can help you see how your kidneys are doing over time. It also helps your healthcare team know whether your current treatment is protecting your kidneys or if changes are necessary.
In this article, we’ll explain what a urine protein test measures, what counts as a normal or high protein level, and what you can expect when you give a urine sample.
When the kidneys are healthy, they act like filters. They keep proteins, which are important building blocks in the body, in your bloodstream. At the same time, they get rid of extra water and waste products.
When kidneys become damaged, as happens when you have IgAN, protein can leak from the bloodstream into the urine. The urine test results give doctors an idea of how much protein is being lost in your urine.
Dipsticks are quick tests that can estimate protein levels almost immediately using a color scale. A test strip is dipped into a urine sample to reveal how much protein is present on the following scale:
Although a dipstick test is less accurate than a lab test, it’s a low-cost and quick way to monitor major changes in the amount of protein in your urine.
Although a dipstick test is less accurate than a lab test, it’s a low-cost and quick way to monitor major changes in the amount of protein in your urine.
Total protein is one of the common indicators found in a urinalysis, or a basic urine test. This number is the total amount of protein in a urine sample. It tests for the overall amount of protein, but it doesn’t tell the difference between different types of protein.
This test is often used for an initial screening. If your total urine protein is elevated, your healthcare provider will likely order more specific tests to gather additional information.
Albumin is the most common protein found in the blood. If the kidneys’ filters are damaged, albumin is often one of the first proteins to leak into the urine because there is so much of it and it’s relatively small in size. In IgAN, urine albumin levels may rise when kidney damage or disease activity worsens.
Your doctor may ask you to collect your urine for 24 hours to measure albumin (or total protein) over a full day. This helps smooth out normal changes that happen throughout the day and gives a more accurate picture of how much protein is leaking from your kidneys.
Creatinine is a waste product that your body makes at a steady rate. A test of your urine protein/creatinine ratio (UPCR) compares the amount of protein with the amount of creatinine in a single urine sample, which helps account for how concentrated the urine is. Comparing protein to creatinine helps doctors understand how much protein you’re losing throughout the day.
This test is helpful because it avoids the need for a full 24-hour urine collection test.
Similar to the protein/creatinine ratio, a test of your urine albumin/creatinine ratio (ACR or uACR) specifically measures albumin loss compared to creatinine. It’s one of the most important tests for detecting early kidney damage, as albumin is usually the first protein to be seen in the urine in IgAN. This test is also critical for tracking kidney health over time.
IgAN damages the kidney’s filtering units, which are called glomeruli. When immunoglobulin A (IgA) builds up in these filters, it causes inflammation and makes them leaky. As a result, protein that should stay in the bloodstream can spill into the urine.
Tracking protein over time helps your care team:
Lowering your urine protein levels is one of the most important goals in IgAN management.
Lowering your urine protein levels is one of the most important goals in IgAN management.
You may take a urine test at home, in your doctor’s office, at the hospital, or in the lab. Different types of tests provide different information.
One general rule is that you should avoid intense exercise the day before a protein test. Exercise may falsely elevate urine protein levels. Let your doctor know if you have a fever, menstrual bleeding, or a urinary tract infection at the time of your test, as these can also alter your test results.
Some people with IgAN use home testing to monitor their protein level between checkups. During a dipstick test, you dip a test strip into your urine. Based on the levels of protein in your urine, the test strip changes color. By comparing the color to the scale on the bottle, you can estimate how elevated your urine protein is.
This test is fast and easy. It can help you track changes in your urine protein at home. However, dipsticks are less precise than lab tests and can’t measure exact amounts.
You may give a sample during your visit or bring it to a lab. Lab testing provides exact numbers, like uACR or UPCR. With a 24-hour urine collection, you can see exactly how much protein you lose in a 24-hour period. Lab tests can confirm an abnormal dipstick result and provide a more precise measurement of the amount of protein in your urine.
Some changes may mean it’s time to call your doctor. If you notice a sudden jump in your home dipstick results (such as trace to 2+ or higher), or notice a rising uACR or UPCR on your lab tests, talk to your doctor about how your IgAN is being managed.
If you notice a sudden jump in your home dipstick results or a rising uACR or UPCR on your lab tests, talk to your doctor about how your IgAN is being managed.
Symptoms to look out for that could signify protein being lost in the urine include:
When you’re sick, dehydrated, or stressed, your protein levels may worsen. By communicating well with your healthcare team, you can ensure that you’re taking good care of your kidneys and overall health.
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